Research Article Open Access

Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice

A. Lemhadri1, Mohamed Eddouks1, Thierry Sulpice1 and Remy Burcelin1
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Abstract

This study was undertaken in order to evaluate the possible anti-hyperglycaemic and body weight reducing activities of the aqueous extract of both Capparis spinosa (CS) and Chamaemelum nobile (CN) (20 mg/kg-1). The results demonstrate clearly that repeated oral administration of both CS and CN aqueous extract evoked a potent anti-hyperglycaemic activity in high fat diet (HFD) obese mice. Postprandial hyperglycaemic peaks were significantly lower in plant-treated experimental groups. In other hand, body weight was significantly lower in CS and CN-treated groups when compared to the control one after daily oral administration of CS and CN aqueous extracts for 15 days. We can conclude that these plants evoked potent anti-hyperglycaemic and anti-obesity effects. This fact could support their use by the Moroccan population for diabetes control and treatment.

American Journal of Pharmacology and Toxicology
Volume 2 No. 3, 2007, 106-110

DOI: https://doi.org/10.3844/ajptsp.2007.106.110

Submitted On: 2 March 2007 Published On: 30 September 2007

How to Cite: Lemhadri, A., Eddouks, M., Sulpice, T. & Burcelin, R. (2007). Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice. American Journal of Pharmacology and Toxicology, 2(3), 106-110. https://doi.org/10.3844/ajptsp.2007.106.110

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Keywords

  • High fat diet
  • obesity
  • oral administration
  • body weight
  • mice