Research Article Open Access

Standard Versus Specific Therapy for Chronic Osteomyelitis Treatment

Angela Ingianni1, Giorgio Lampis1, Samuela Laconi1, Donatina Cariello1 and Raffaello Pompei1
  • 1 Università di Pisa, Italy

Abstract

58 patients with chronic osteomyelitis were treated either with a standard therapy or with a specific targeted therapy based on the antibiogram assay. Standard therapy was performed by a 15-day course of a parenteral cephalosporin (usually ceftriaxone) in combination with an aminoglycoside (e.g. netilmicin), followed by oral therapy with a fluoroquinolone (generally ciprofloxacin) for 1 to 3 months; specific therapy largely varied depending on the antibiogram response. The results indicated that no significant differences were found between the patients who received standard therapy (95.5 % cured) and those who received a specific therapy (93.5 % cured), after a one year follow-up. It can be concluded that a short-term combined parenteral-oral standard therapy, indicated in all those cases where antibiotic therapy must be started before obtaining the laboratory response, or when a clear and definite identification of the microorganisms involved in the infection is not possible, can be as efficient as an antibiogram-guided therapy in the treatment of chronic osteomyelitis.

American Journal of Infectious Diseases
Volume 3 No. 3, 2007, 128-133

DOI: https://doi.org/10.3844/ajidsp.2007.128.133

Submitted On: 13 April 2007 Published On: 30 September 2007

How to Cite: Ingianni, A., Lampis, G., Laconi, S., Cariello, D. & Pompei, R. (2007). Standard Versus Specific Therapy for Chronic Osteomyelitis Treatment. American Journal of Infectious Diseases, 3(3), 128-133. https://doi.org/10.3844/ajidsp.2007.128.133

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Keywords

  • Chronic osteomyelitis
  • Standard therapy
  • Quinolones
  • Ceftriaxone
  • Staphylococci
  • Microbial resistance