American Journal of Infectious Diseases

Standard Versus Specific Therapy for Chronic Osteomyelitis Treatment

Angela Ingianni, Giorgio Lampis, Samuela Laconi, Donatina Cariello and Raffaello Pompei

DOI : 10.3844/ajidsp.2007.128.133

American Journal of Infectious Diseases

Volume 3, Issue 3

Pages 128-133


58 patients with chronic osteomyelitis were treated either with a standard therapy or with a specific targeted therapy based on the antibiogram assay. Standard therapy was performed by a 15-day course of a parenteral cephalosporin (usually ceftriaxone) in combination with an aminoglycoside (e.g. netilmicin), followed by oral therapy with a fluoroquinolone (generally ciprofloxacin) for 1 to 3 months; specific therapy largely varied depending on the antibiogram response. The results indicated that no significant differences were found between the patients who received standard therapy (95.5 % cured) and those who received a specific therapy (93.5 % cured), after a one year follow-up. It can be concluded that a short-term combined parenteral-oral standard therapy, indicated in all those cases where antibiotic therapy must be started before obtaining the laboratory response, or when a clear and definite identification of the microorganisms involved in the infection is not possible, can be as efficient as an antibiogram-guided therapy in the treatment of chronic osteomyelitis.


© 2007 Angela Ingianni, Giorgio Lampis, Samuela Laconi, Donatina Cariello and Raffaello Pompei. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.