@article {10.3844/ajidsp.2007.128.133,
article_type = {journal},
title = {Standard Versus Specific Therapy for Chronic Osteomyelitis Treatment},
author = {Ingianni, Angela and Lampis, Giorgio and Laconi, Samuela and Cariello, Donatina and Pompei, Raffaello},
volume = {3},
number = {3},
year = {2007},
month = {Sep},
pages = {128-133},
doi = {10.3844/ajidsp.2007.128.133},
url = {https://thescipub.com/abstract/ajidsp.2007.128.133},
abstract = {58 patients with chronic osteomyelitis were treated either with a standard therapy or with a specific targeted therapy based on the antibiogram assay. Standard therapy was performed by a 15-day course of a parenteral cephalosporin (usually ceftriaxone) in combination with an aminoglycoside (e.g. netilmicin), followed by oral therapy with a fluoroquinolone (generally ciprofloxacin) for 1 to 3 months; specific therapy largely varied depending on the antibiogram response. The results indicated that no significant differences were found between the patients who received standard therapy (95.5 % cured) and those who received a specific therapy (93.5 % cured), after a one year follow-up. It can be concluded that a short-term combined parenteral-oral standard therapy, indicated in all those cases where antibiotic therapy must be started before obtaining the laboratory response, or when a clear and definite identification of the microorganisms involved in the infection is not possible, can be as efficient as an antibiogram-guided therapy in the treatment of chronic osteomyelitis.},
journal = {American Journal of Infectious Diseases},
publisher = {Science Publications}
}