American Journal of Applied Sciences

Antimicrobial Activities of Unconventional Compounds against Some Bacteria Associated with Skin Infections in Humans, Sheep and Goats

Iman Shabana and Amira El-Adly

DOI : 10.3844/ajassp.2016.36.45

American Journal of Applied Sciences

Volume 13, Issue 1

Pages 36-45


Bacterial skin infections are a common problem encountered in clinical practice and causing great economic losses for sheep and goats producers. Increasing multidrug resistance of pathogens paves the way for reconsidering alternative medicine. The present study was carried out to explore the antibacterial activities of different volumes; 5, 25, 50 and 100 µL of gold nanoparticles (NPS) and the aqueous and ethanolic extracts of garlic, turmeric and cinnamon at different concentrations (20, 40, 80 and 100%) against molecularly confirmed Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli isolated from skin pyogenic lesions in humans, sheep and goats using disc diffusion assay. The results compared with ciprofloxacin (5 µg mL-1). Gold nanoparticles (NPS) 100 µL were highly effective against Pseudomonas aeruginosa and Escherichia coli in comparing with ciprofloxacin (5 µg mL-1). Garlic has shown better activity against Staphylococcus aureus and Streptococcus pyogenes in aqueous solution while the ethanolic extract of cinnamon and turmeric was more efficient than the aqueous extract. Among the three tested spices, turmeric was the least effective against tested bacteria. The proven activity of 100 µL Gold nanoparticles (NPS) and 100% aqueous garlic extract compared with ciprofloxacin (5 µg mL-1), suggests their use in clinical trials as an alternative medicine to reduce the side effects and progressively increasing drug resistance of pathogens.


© 2016 Iman Shabana and Amira El-Adly. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.