American Journal of Applied Sciences

Association of Oral Contraceptives and Abnormal Pap Smear

Sayedmohsen Sayednozadi, Mohammadreza Hassany and Mohammad A. Ramezani

DOI : 10.3844/ajassp.2005.1150.1152

American Journal of Applied Sciences

Volume 2, Issue 7

Pages 1150-1152


To assess the hypothesis that combined Oral Contraceptive (OCs) increase the risk of cervical neoplasia, we conducted a multicenter Case-Control study in Mashhad, the capital of Khorasan province. Seventy-eight women with moderate to severe dysplasia at Pap smear as case group and one hundred fifty nine women with normal Pap smear were selected as the control group for evaluation. The both case and control groups were matched by age, parity and socioeconomic status. All of the women in this study were single partner as husband and no smoker. 30 percent of cases and 64.8 percent of controls were used OCs. The duration of OCs use was the same in both. The odds ratio for OCs consumption was 0.2 with 95% confidence interval 0.11-0.4 in Logistic regression analysis. In contrast to some other studies, our findings showed an association between OCs and cervical dysplasia and there was a protective effect of OCs for cervical dysplasia.


© 2005 Sayedmohsen Sayednozadi, Mohammadreza Hassany and Mohammad A. Ramezani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.