Serotonergic Properties of the Roots of Clerodendron capitatum
- 1 University Putra Malaysia, Malaysia
- 2 Medicinal and Aromatic Plants Institute, Malaysia
- 3 University of Khartoum, Sudan
Abstract
The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.
DOI: https://doi.org/10.3844/ajbbsp.2008.425.430
Copyright: © 2008 Siddig Ibrahim Abdel Wahab, Abdel Wahab Hassan Mohamed, Osama Yousif Mohamed, Manal Mohamed Elhassan Taha, Ahmad Bustamam Abdul and Adel Sharaf Al-Zubairi. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Clerodendrum capitatum
- adrenergic
- cholinergic effects
- 5-HT