Structural Characterization at the Atomic Level of a Molecular Nano-Machine: The State of the Art of Helicobacter Pylori Flagellum Organization
Ivana Pulić, Valentina Loconte and Giuseppe Zanotti
DOI : 10.3844/ajbbsp.2014.143.161
American Journal of Biochemistry and Biotechnology
Volume 10, Issue 3
Motility is fundamental for success in colonization and survival of the human pathogen H. pylori, the bacterium that colonizes about half of the human population. Motility is achieved through flagella. In this review the present structural knowledge about the organization of H. pylori flagella is summarized, considering not only the structure of its proteins, but also what is known about flagella of other Gram-negative bacteria. Despite the limited amount of structural information about the H. pylori nano-machinery, sequence alignments and homology modeling allow to investigate the unique structural properties of several H. pylori flagellar proteins.
© 2014 Ivana Pulić, Valentina Loconte and Giuseppe Zanotti. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.