METHYLENETETRAHYDROFOLATE REDUCTASE (677C/T) POLYMORPHISM IN MYOCARDIAL INFARCTION AND HYPERTENSION

Hatem Al-Kordy Amin, Hanaa Fahmy Abdel Aziz, Ola Farouk Leheta and Hanan Kamal

DOI : 10.3844/ajbbsp.2012.150.156

American Journal of Biochemistry and Biotechnology

Volume 8, Issue 3

Pages 150-156

Abstract

Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease and hypertension. This study aimed to assess the MTHFR gene polymorphisms (677C/T) as a potential genetic risk factor for hypertension and Myocardial Infarction (MI) in Egypt. Myocardial infarction and hypertensive diagnosed patients were divided into two groups; first comprised 50 patients aged < 45 years, second comprised 47 patient aged > 45 years and a third control group comprised 84. CT genotype was significantly higher in the first group (48.8%) versus control group (30%) and second group (29.4%) with (OR 2.35, 95% CI 1.3-4.2, p = 0.006). The percentage of TT genotype was 4.7, 11.8 and 15% in the three groups respectively. The percentage of MTHFR 677C→T polymorphism was significantly higher in patients with hypertension than normotensive. MTHFR 677C→T polymorphism in Egyptian MI and hypertensive patients has no direct role in developing such diseases but in combination with high levels of cholesterol, LDL-C and triglycerides might constitute a probable potentiating factor for MI and hypertension among Egyptian patients and could not be used as a predictor for early diagnosis without considering other factors.

Cite this Article

Amin, H.A.K., H.F.A. Aziz, O.F. Leheta and H. Kamal, 2012. Methylenetetrahydrofolate reductase (677C/T) polymorphism in myocardial infarction and hypertension. Am. J. Biochem. Biotechnol., 8: 150-156.