Methylenetetrahydrofolate Reductase (677C/T) Polymorphism in Myocardial Infarction and Hypertension
Hatem Al-Kordy Amin, Hanaa Fahmy Abdel Aziz, Ola Farouk Leheta and Hanan Kamal
DOI : 10.3844/ajbbsp.2012.150.156
American Journal of Biochemistry and Biotechnology
Volume 8, Issue 3
Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease and hypertension. This study aimed to assess the MTHFR gene polymorphisms (677C/T) as a potential genetic risk factor for hypertension and Myocardial Infarction (MI) in Egypt. Myocardial infarction and hypertensive diagnosed patients were divided into two groups; first comprised 50 patients aged < 45 years, second comprised 47 patient aged > 45 years and a third control group comprised 84. CT genotype was significantly higher in the first group (48.8%) versus control group (30%) and second group (29.4%) with (OR 2.35, 95% CI 1.3-4.2, p = 0.006). The percentage of TT genotype was 4.7, 11.8 and 15% in the three groups respectively. The percentage of MTHFR 677C→T polymorphism was significantly higher in patients with hypertension than normotensive. MTHFR 677C→T polymorphism in Egyptian MI and hypertensive patients has no direct role in developing such diseases but in combination with high levels of cholesterol, LDL-C and triglycerides might constitute a probable potentiating factor for MI and hypertension among Egyptian patients and could not be used as a predictor for early diagnosis without considering other factors.
© 2012 Hatem Al-Kordy Amin, Hanaa Fahmy Abdel Aziz, Ola Farouk Leheta and Hanan Kamal. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.