American Journal of Biochemistry and Biotechnology

Gene Technology in Tissue Engineering

Xiao-Dan Sun and In-Seop Lee

DOI : 10.3844/ajbbsp.2006.66.72

American Journal of Biochemistry and Biotechnology

Volume 2, Issue 2

Pages 66-72


Scaffold, cells and signaling factors are regarded as the three essential components in tissue engineering. With the development of molecular and cell biology, gene technology is beginning to show a promising position in tissue engineering as it can influence these essential components at DNA-level. By introducing plasmid DNA or genes encoding certain signaling factors (growth factors/cytokines) into the cells, required growth factors/cytokines can be expressed and secreted spatially and temporally by the transfected cells, which will promote the differentiation, proliferation and organization of the cells on the scaffold. Protein-based scaffolds which have specific structures can also be prepared genetically to induce attachment and spreading of the cells. This paper reviews research work of gene technology developed in tissue engineering.


© 2006 Xiao-Dan Sun and In-Seop Lee. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.