@article {10.3844/ojbsci.2025.780.789,
article_type = {journal},
title = {Evaluating the Hepatoprotective and Anti-Inflammatory Efficacy of Herbal Extracts for NAFLD Prevention},
author = {Al-Muzafar, Hessah Mohammed and Amin, Kamal Adel},
volume = {25},
number = {3},
year = {2025},
month = {Nov},
pages = {780-789},
doi = {10.3844/ojbsci.2025.780.789},
url = {https://thescipub.com/abstract/ojbsci.2025.780.789},
abstract = {Natural products may offer a safer approach for mitigating the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD). This study aimed to evaluate the hepatoprotective and anti-inflammatory effects of a water-based extract of Moringa Oleifera leaf, Milk Thistle, and Cassia (MO-MT-CA) against High-Fat, High-Sugar Diet (HFSD)-induced fatty liver. The research focuses on assessing lipid profiles and inflammation as key markers of its potential effect. The experimental animals were allocated randomly into 3 groups: 1st healthy group was fed a standard diet, 2nd group was fed a HFSD for 12 weeks, and 3rd group was given HFSD or MO-MT-CA for 4 weeks. Lipid profiles, hepatic function, and inflammatory biomarkers were measured in each group. HFSD-fed rats showed elevated serum triglycerides, cholesterol, and low-density lipoproteins LDL levels. Hepatic function tests were significantly higher than in healthy rats. HFSD also increased inflammatory markers, such as Tumor Necrosis Factor (TNF-α) and interleukin 6 (IL-6), as well as lipid metabolism hormones (leptin and resistin). The study introduces a potentially novel herbal blend, MO-MT-CA, and examines its beneficial impact on lipid metabolism, liver function, and inflammation, which may contribute to new therapeutic approaches for NAFLD.},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}