@article {10.3844/ojbsci.2025.601.606,
article_type = {journal},
title = {Exploring the Role of Vitamin B12 as an Anti-atherogenic and Anti-inflammatory Agent in Apparently Healthy Adults With Hypovitaminosis D},
author = {Panchwadkar, Shravan Ajith and Kuthethur, Sudha and Kollampare, Sowndarya and Pawar, Neelam Manjunath},
volume = {25},
number = {3},
year = {2025},
month = {Jul},
pages = {601-606},
doi = {10.3844/ojbsci.2025.601.606},
url = {https://thescipub.com/abstract/ojbsci.2025.601.606},
abstract = {Vitamin B12 deficiency is associated with metabolic changes like methyl malonic acidemia and hyperhomocystinemia eventually leading to atherosclerosis. Dyslipidemia and vitamin D (vit D) deficiency are independent risk factors of CVD. This study aims to explore the interrelationship between inflammatory markers, adverse lipid profile and vitamin B12 in hypovitaminosis D. Since, atherosclerosis is an inflammatory condition we have investigated CRP and NLR as inflammatory markers along with lipid profile parameters and atherogenic indices in apparently healthy individuals with vitamin D deficiency. 90 apparently healthy subjects aged between 25-55 years were divided into 3 groups of 30 members each, as vit D sufficient (vit D ≥ 30 ng/ml), insufficient (vit D = 21-29 ng/ml) and deficient groups (vit D ≤ 20 ng/ml). Deficient group was further divided into moderately and severely deficient (vit D less than 20 and 10 ng/ml) groups respectively. Fasting lipid profile was estimated spectrophotometrically. Plasma vit D and B12 were determined by ECLIA. CRP was assayed by ELISA. Neutrophil Lymphocyte Ratio (NLR) was calculated manually. Vitamin B12 was significantly lower in vit D deficient group compared to insufficient (p},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}