@article {10.3844/ojbsci.2025.219.231, article_type = {journal}, title = {Epidemiological Insights and Case Fatality Analysis of SARS-CoV-2 in Indian States During the First Wave}, author = {Kaushik, Rakesh and Nikita, and Lugani, Yogita and Kumaresan, Gururaj and Gupta, Saurabh and Arya, Aditya and Chatli, Manish Kumar and Dass, Gopal and Rishabh,}, volume = {25}, number = {1}, year = {2025}, month = {Jan}, pages = {219-231}, doi = {10.3844/ojbsci.2025.219.231}, url = {https://thescipub.com/abstract/ojbsci.2025.219.231}, abstract = {Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has globally spread, causing a significant health crisis. India, with over 157,000 fatalities, ranks third globally in mortality cases. While vaccine development has played a pivotal role in decelerating the virus's spread, understanding the specific factors influencing morbidity and mortality during the first wave remains essential. This retrospective study analyzes data from 28 Indian states and 8 Union Territories (UTs) to examine transmission pathways and Case Fatality Rate (CFR) associated with SARS-CoV-2. Data sources include national health records and government databases, encompassing all confirmed cases reported during the study period. The CFR was calculated using standard epidemiological formulas, with statistical analyses performed using least squares means analysis (Harvey Software). The study reveals significant variations in CFR across different geographical zones in India: Central (17%), Eastern (14%), North Eastern (7%), Northern (22%), Southern (12%) and Western (28%). Period II (April to June 2020) showed significantly higher CFR (p}, journal = {OnLine Journal of Biological Sciences}, publisher = {Science Publications} }