@article {10.3844/ojbsci.2024.263.273,
article_type = {journal},
title = {A Static Magnetic Field Exposure in Obese Mice Induced by High Fat Diet: Its Effect on T-Box15 Gene and Uncoupling Protein 1 Expression},
author = {Oktaviani, Widia Bela and Sari, Puji and Yunaini, Luluk and Umiatin, and Suryandari, Dwi Anita},
volume = {24},
number = {2},
year = {2024},
month = {Jan},
pages = {263-273},
doi = {10.3844/ojbsci.2024.263.273},
url = {https://thescipub.com/abstract/ojbsci.2024.263.273},
abstract = {Increased Ca2+ cytosolic concentration caused by Static Magnetic Field (SMF) exposure modulates Tbx15 protein and Ucp1 gene interaction that is involved in the thermogenesis browning process of white adipose tissue. Activation of Tbx15 as a transcription factor that regulates the expression of the Uncoupling protein 1 (Ucp1) gene induced by SMF exposure in adipose tissue converts excess accumulated fat into heat. This discovery has led to a novelty in preventing obesity. Experimental studies to determine the effect of SMF on the browning process have not been widely reported. Hence, we investigated its effect on lee index, Tbx15, and Ucp1 expression, as well as adipose cell size in obese mice inguinal adipose tissue. This study used two control groups, namely normal and obese mice. We generated C57BL/6J obese mice only by inducing a High-Fat Diet (HFD). Mice were exposed to SMF at a 2 mT intensity for 1 h per day for 21 days of adipocyte differentiation. Lee index, Tbx15 protein, Ucp1 gene, and histological inguinal adipose histology were all investigated. Tbx15 expression increased after 2-7 days of SMF exposure and Lee index decreased significantly (p},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}