@article {10.3844/ojbsci.2024.178.188,
article_type = {journal},
title = {Hepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in Rats},
author = {Serra, Fernanda Maria and Magalhães, Letícia Rocha and Silva, Beatriz Bertholace Magalhães and Barreiro, Emmanuela Beatriz Vantini and Franco, Isabela Benes and Nogueira, Isabela Melo and Benatti, Liliane Aparecida Tanus and Nai, Gisele Alborghetti},
volume = {24},
number = {2},
year = {2023},
month = {Dec},
pages = {178-188},
doi = {10.3844/ojbsci.2024.178.188},
url = {https://thescipub.com/abstract/ojbsci.2024.178.188},
abstract = {Glyphosate's remarkable effectiveness in weed control has made it among the foremost widely employed herbicides globally. Several Glyphosate-Based Herbicides (GBHs) contain 1-4 dioxane, a compound known to induce cancer in animals and potentially contribute to liver and kidney damage in humans. The objective was to assess the liver and kidney toxicity resulting from sub-chronic exposure to GBH in rats. Eighty wistar rats were divided into 8 groups, each consisting of 5 males and 5 females. These groups were categorized into 4 inhalation exposure groups and 4 oral exposure groups. The control groups were subjected to exposure to sodium chloride solution, while the other groups were exposed to GBH at low, medium, and high concentrations. This exposure continued for 75 days. Blood samples were taken for the assessment of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), creatinine, and urea levels, and the liver, kidney, pancreas and spleen tissues were sampled for histopathology. The females in the high oral concentration group exhibited the most elevated levels of AST, ALT, and urea (p},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}