@article {10.3844/ojbsci.2022.177.190,
article_type = {journal},
title = {Effect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F Cells},
author = {Kgopa, Ananias Hodi and Makhubela, Sebolaishi Doris and Mogale, Motetelo Alfred and Shai, Leshweni Jerry},
volume = {22},
number = {2},
year = {2022},
month = {Apr},
pages = {177-190},
doi = {10.3844/ojbsci.2022.177.190},
url = {https://thescipub.com/abstract/ojbsci.2022.177.190},
abstract = {Cinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption as well as glucose-stimulated insulin synthesis and secretion by RIN-m5F cells. All C. cassia extracts did not enhance glucose consumption when compared to the untreated cells (p˂0.001). However, lower concentrations of the extracts significantly increased mRNA levels of Glucose Transporter 2 (GLUT2) and glucokinase genes. Furthermore, all C. cassia extracts significantly stimulated/increased total insulin synthesis (intracellular and secreted) when compared with the control cells, though the effect was not dose-dependent except for water extracts at higher concentration (p},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}