@article {10.3844/ojbsci.2021.267.279, article_type = {journal}, title = {The Antinociceptive Effects of Central and Peripheral Administration of Peganum harmala L. Extracts in Animal Models}, author = {Aboufatima, Rachida and Farouk, Loubna and Laaradia, Mehdi Ait and Oufquir, Sara and Jawad, Laadraoui and El Alami, Abderrazak and El Gabbas, Zineb and Bezza, Kenza and Marhoume, Fatim Zahra and Sokar, Zahra and Chait, Abderrahman}, volume = {21}, number = {2}, year = {2021}, month = {May}, pages = {267-279}, doi = {10.3844/ojbsci.2021.267.279}, url = {https://thescipub.com/abstract/ojbsci.2021.267.279}, abstract = {The medicinal plant Peganum harmala has been used in traditional Moroccan medicine to accelerate the healing process of various diseases and to relieve the pain. The antinociceptive effect of the Aqueous (AE), Dichloromethane (DE) and Butanolic (BE) extracts of the Peganum harmala L. was tested in mice and rats by chemical and thermal models. Plant seed extracts were given intraperitoneally 30 min before the 0.6% acetic acid injection. Dichloromethane (DE) at doses of 25 mg/kg (68.4%; p}, journal = {OnLine Journal of Biological Sciences}, publisher = {Science Publications} }