@article {10.3844/ojbsci.2018.358.364, article_type = {journal}, title = {The Role of Receptor Activator of Nuclear Factor Kappa B (RANK) and Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) in Osteoporosis Risk: Gene Polymorphism and Soluble RANKL Level in Indonesia Post-Menopausal Women}, author = {Yunaini, Luluk and Suryandari, Dwi Anita and Kusdhany, Linda and Kurniati, Mala and Reihannisha, Indhina and Auerkari, Elza Ibrahim}, volume = {18}, number = {3}, year = {2018}, month = {Sep}, pages = {358-364}, doi = {10.3844/ojbsci.2018.358.364}, url = {https://thescipub.com/abstract/ojbsci.2018.358.364}, abstract = {Hormonal changes in postmenopausal women may increase osteoclastogenesis that can lead to increased risk of osteoporosis. Receptor Activator of Nuclear factor Kappa B (RANK) and Receptor Activator of Nuclear factor Kappa B Ligand (RANKL) have an important role in osteoclastogenesis that involve in the regulation of bone resorption. In this study, we analyzed the Single Nucleotide Polymorphism (SNPs) within the RANK/RANKL gene and the associated sRANKL level to assess the risk of osteoporosis in postmenopausal Indonesian women. Research was conducted as case control study that involved 210 postmenopausal Indonesian women. 105 of the women were classified as osteoporosis and 105 as normal. Genetic analysis was performed by PCR-RFLP. BMD was measured by Dual energy X-ray Absorptiometry (DXA) and the RANKL serum level was determined by ELISA. For statistical analysis, Chi-square testing, Kruskal Wallis testing, Mann-Whitney U testing and odds ratio testing were mainly applied, with a significance level of p}, journal = {OnLine Journal of Biological Sciences}, publisher = {Science Publications} }