@article {10.3844/ajptsp.2009.169.173,
article_type = {journal},
title = {Evaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino Rats},
author = {Utoh-Nedosa, A. U. and Akah, P. A. and Okoye, T. C. and Okoli, C. O.},
volume = {4},
year = {2009},
month = {Dec},
pages = {169-173},
doi = {10.3844/ajptsp.2009.169.173},
url = {https://thescipub.com/abstract/ajptsp.2009.169.173},
abstract = {Problem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin (DHA), a member of the artemisinin family, to produce toxic effect in the vital organs (such as the liver, heart, lungs, intestine, spleen kidney and blood cells) necessitated this research. Approach: Rats were treated once orally with DHA (2 mg kg-1) on day 1 and then (1 mg kg-1) on day 2-5 and the treatment was repeated 7 days after the first treatment. The animals were sacrificed 24 h after the second treatment for toxicity studies on the vital organs and liver enzymes activity tests: Serum Alanine amino Transferase (ALT), Serum Aspartate amino Transferase (AST) and serum Alkaline Phosphatase (ALP) tests. Results: Results indicated that dihydroartemisinin significantly (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}