TY  - JOUR
AU  - Ahmed, Lemhadri 
AU  - Burcelin, Remy 
AU  - Sulpice, Thierry 
AU  - Eddouks, Mohamed 
PY  - 2007
TI  - Chamaemelum nobile L. Aqueous Extract Represses Endogenous Glucose Production and Improves Insulin Sensitivity in Streptozotocin-induced Diabetic Mice 
JF  - American Journal of Pharmacology and Toxicology
VL  - 2
IS  - 3
DO  - 10.3844/ajptsp.2007.116.122
UR  - https://thescipub.com/abstract/ajptsp.2007.116.122
AB  - The present study was undertaken in order to evaluate the possible mechanisms of action involved in the hypoglycaemic activity of the aqueous extract of Chamaemelum nobile (CN) (20 mg kg-1). This study was carried out in multi low-dose streptozotocin-induced (MLDS) diabetic mice. Hypoglycaemic effect of CN was studied after both single and repeated oral administration of CN aqueous extract (20 mg kg-1). Endogenous glucose production was estimated using primed-continuous 3-3H glucose infusion technique. While, euglycemic hyperinsulinemic glucose clamp technique was used to assess peripheral insulin sensitivity. Both single and repeated oral administration (s) of aqueous CN extract evoked a prominent hypoglycaemic activity in MLDS diabetic mice. In other hand, 3-3H glucose infusion demonstrated that this hypoglycaemic activity was accompanied by a decrease in basal endogenous glucose production (EGP). EGP was lower in CS-treated group when compared to the control group, 15.5±0.5 vs 27.2±7.1 mg kg-1 min-1 (p