@article {10.3844/ajisp.2017.1.10,
article_type = {journal},
title = {Regulation of Gene Expression by β-Glucans},
author = {Huff, Mary O. and Klinge, Carolyn M.},
volume = {13},
year = {2017},
month = {Apr},
pages = {1-10},
doi = {10.3844/ajisp.2017.1.10},
url = {https://thescipub.com/abstract/ajisp.2017.1.10},
abstract = {β-D-glucans are diverse polysaccharides derived from plant cell walls, fungi and bacteria. β-D-glucans are composed of D-glucose monomers linked by (1-3) β-glycosidic bonds with varying amounts of (1-6) or (1-4) linked side chains that bind cell surface receptors ultimately triggering changes in intracellular pathways and gene transcription. β-D-glucans have anti-viral, immunomodulatory and anti-cancer activities. This article reviews the current identity and putative function of genes regulated by β-glucans purified from various sources in human cancer and immune cells and in murine dendritic, macrophage cells and lungs. β-D-glucans increase the expression of numerous cytokines and immunomodulatory factors and their receptors in dendritic cells. Pathways and transcription factors involved in the cellular responses to β-glucans are summarized.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}