TY  - JOUR
AU  - Gomez, Gabriel Andres Tafur 
AU  - Vargas, Marlene Isabel 
AU  - Salcedo, Joaquin Hernan Patarroyo 
AU  - Souza, Elisangela Neves de 
AU  - Sossai, Sidimar 
AU  - Arujo, Leandro de 
AU  - Peconik, Ana Paula 
AU  - Kalks, Karlos Henrique Martins 
PY  - 2013
TI  - Immunological Response in Bovine Lymph Nodes Stimulated with Subunits Vaccines
JF  - American Journal of Immunology
VL  - 9
IS  - 2
DO  - 10.3844/ajisp.2013.48.57
UR  - https://thescipub.com/abstract/ajisp.2013.48.57
AB  - The vaccination process belongs to the public health intervention methodologies that help prevent infections. Vaccinations performed successfully in the history of medicine reported the significance of this procedure to increase the quality of life, prevent zoonoses and improve animal production. Vaccine emergence remained without exact rules for a long time, maintaining a close relationship with pathogens. However, subunit vaccines, with a difference from the classical idea of protective immunity with microorganisms showed it is possible to trigger T-dependent responses with peptide, revealing new rules for vaccine development. This vaccination process starts by the modulation chance of adaptive immune response through peptide sequences process by APCs for immune synapse formation interceded for pMHC-TCR as a scaffold to T cells priming. In this way the immunological signal triggered by immune synapses is amplified in lymph nodes. As a consequence, T and B cells modulated by peptide activity interact between the B cell follicles region and T cell aggregates, which constitute the paracortical region of secondary lymphoid tissue to form connate unions as a prerequisite for clonal amplification and subsequent immunological memory. Indicating the knowledge of the mechanisms of immune response generated by peptides immunization is essential for understanding modulation, amplification and immune protection as demands for good subunits vaccine.