TY  - JOUR
AU  - Vaclav, Vetvicka 
AU  - Josef, Richter 
AU  - Vladimir, Svozil 
AU  - Lucie, Rajnohova Dobiasova 
AU  - Vlastimil, Kral 
PY  - 2013
TI  - Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children with Chronic Respiratory Problems: Antibody Production
JF  - American Journal of Immunology
VL  - 9
IS  - 2
DO  - 10.3844/ajisp.2013.43.47
UR  - https://thescipub.com/abstract/ajisp.2013.43.47
AB  - The role of glucan in stimulation of immune reactions has been well-established. In this report, we focused on the antibody production in glucan-supplemented children with chronic respiratory problems. We measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effects of 100 mg d-1 oral dose of glucan. We found a significant increase in production of all tested antibodies in the glucan-stimulated group, but a decrease of antibody production in the control group. A thirty-day oral application of yeast-based natural immunomodulator β-glucan strongly stimulated the mucosal immunity of children with chronic respiratory problems.