TY  - JOUR
AU  - Schumann, J. 
PY  - 2010
TI  - Transforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine System
JF  - American Journal of Immunology
VL  - 6
IS  - 2
DO  - 10.3844/ajisp.2010.20.24
UR  - https://thescipub.com/abstract/ajisp.2010.20.24
AB  - Since their first description only some years ago Th17 cells have become of vital
importance in immunological research. However, the role of TGF-β in Th17 cell development is still a
matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the
mouse TGF-β was shown to inhibit IL-17 production of human CD4+ T cells. Moreover, recent data
indicate TGF-β signaling in T cells to be dispensable for Th17 cell differentiation in the murine
system. Hence, rather being a specie-specific factor TGF-β is likely to act as an indirect inducer of
Th17 cell differentiation both in mice and men.