@article {10.3844/ajisp.2010.20.24,
article_type = {journal},
title = {Transforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine System},
author = {Schumann, J.},
volume = {6},
year = {2010},
month = {Jun},
pages = {20-24},
doi = {10.3844/ajisp.2010.20.24},
url = {https://thescipub.com/abstract/ajisp.2010.20.24},
abstract = {Since their first description only some years ago Th17 cells have become of vital
importance in immunological research. However, the role of TGF-β in Th17 cell development is still a
matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the
mouse TGF-β was shown to inhibit IL-17 production of human CD4+ T cells. Moreover, recent data
indicate TGF-β signaling in T cells to be dispensable for Th17 cell differentiation in the murine
system. Hence, rather being a specie-specific factor TGF-β is likely to act as an indirect inducer of
Th17 cell differentiation both in mice and men.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}