TY  - JOUR
AU  - Kılıc, Nedret 
AU  - Guney, Yildiz 
AU  - Hıcsonmez, Ayse 
AU  - Erol, Melike 
AU  - Kömürcü, Ferhan 
AU  - Dizman, Aysen 
AU  - Turkcu, Ummuhani Ozel 
AU  - Andrieu, Meltem Nalca 
PY  - 2006
TI  - Effects of Two Different Dose Levels of Irradiation on Thioredoxin Reductase in the Kidney of Guinea Pigs
JF  - American Journal of Immunology
VL  - 2
IS  - 2
DO  - 10.3844/ajisp.2006.58.60
UR  - https://thescipub.com/abstract/ajisp.2006.58.60
AB  - It is aimed to examine the state of the oxidant-antioxidant system in the liver of guinea pig caused by ionizing radiation at two different dose levels in the early period. The research was carried out on guinea pigs irradiated with the doses of 8 Gy (group 2) or 15 Gy (group 3) (single dose/whole body) in comparison with control group (group 1). The levels of thioredoxin reductase (TR) in the kidney was measured. The results obtained by non-irradiated and irradiated (8 Gy and 15 Gy) kidneys on guinea pigs indicated that; in 8-15 Gy irradiated animal kidneys TR activity elevated significantly (p<0.001) when compared to the controls, but there was no difference between 8 Gy and 15 Gy irradiated animal groups. The data have shown that gamma-irradiation results in significant increase in TR activity at two different dose levels.