@article {10.3844/ajisp.2006.29.34,
article_type = {journal},
title = {Topical Cyclosporine A in Corneal Graft Rejection},
author = {Nejabat, Mahmood and Khoshghadam, Jafar and Eghtedari, Masoomeh and Hosseini, Hamid},
volume = {2},
year = {2006},
month = {Jun},
pages = {29-34},
doi = {10.3844/ajisp.2006.29.34},
url = {https://thescipub.com/abstract/ajisp.2006.29.34},
abstract = {Corneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with the first episode of endothelial graft rejection in two groups. Group one (20 patients) received topical steroids eye drops and systemic prednisolone (1 mg/kg) by oral route plus placebo. Group two (20 patients) received the same topical and systemic steroid therapy plus 2% cyclosporine A (CSA) eye drop. The patients were followed up for three months and their clinical outcomes were evaluated by the rates and time of rejection reversal. In group one, 14 (70%) cases had total reversal of graft rejection episode but in CSA group, it occurred in 18 (90%) cases (P=0.21) .Improvement were started within a mean period of 3 and 1.5 days respectively (P value},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}