@article {10.3844/ajidsp.2021.88.96,
article_type = {journal},
title = {Relationship between Streptococcus gallolyticus Infective Endocarditis and Pre-Neoplastic Colorectal Lesions},
author = {Vilardell, Pau and Moral, Sergio and Frigola, Josep Maria and Morales, Manel and Ballesteros, Esther and Salgado, Xavier and Castro, Antoni and Rubió, Antoni and Abulí, Marc and Brugada, Ramon},
volume = {17},
number = {3},
year = {2021},
month = {May},
pages = {88-96},
doi = {10.3844/ajidsp.2021.88.96},
url = {https://thescipub.com/abstract/ajidsp.2021.88.96},
abstract = {Colorectal cancer is associated with Infective Endocarditis (IE) due to specific gut pathogens, such as Streptococcus gallolyticus subspecies, that use tumor presence as a point of blood entry. However, the association between Streptococcus gallolyticus related IE and pre-cancerous colorectal lesions like dysplastic adenomas is unclear. Seventy-one patients diagnosed with IE who underwent colonoscopy in the extension study during admission were included in a clinical, microbiological and imaging follow-up, between January 2008 and December 2020. Pre-cancerous lesions were divided as high and low-grade dysplasia based on World Health Organization criteria. Colorectal cancer was defined as the presence of malignant cell beyond the muscularis mucosa. Twenty-two IE patients (31%) presented colorectal lesions: 8 (36%) colorectal cancer and 14 (64%) pre-cancerous lesions [14% high degree (n = 2); 86% low degree (n = 12)]. Both, colorectal cancer (25% Vs 2%; p = 0.007) and pre-neoplastic lesions (50% Vs 2%; p},
journal = {American Journal of Infectious Diseases},
publisher = {Science Publications}
}