TY  - JOUR
AU  - Bhatt, Niraj Mukundray 
AU  - Barua, Suparna 
AU  - Gupta, Sarita 
PY  - 2009
TI  - Protective Effect of Enicostemma littorale Blume on Rat Model of Diabetic Neuropathy
JF  - American Journal of Infectious Diseases
VL  - 5
IS  - 2
DO  - 10.3844/ajidsp.2009.99.105
UR  - https://thescipub.com/abstract/ajidsp.2009.99.105
AB  - Problem statement: Poor glycemic control and oxidative stress 
is implicated as a common pathway in the development of diabetic neuropathy. Approach: 
In the present study, we investigated the protective effects of Enicostemma 
littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine 
in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: 
Tail flick latency in hot immersion test and the formalin test were used 
to evaluate nociceptive responses in diabetic rats compared to non-diabetic rats. 
Preventive treatment of EL (for 45 days) and standard drug glibenclamide (Glib) 
significantly improved nociception in diabetic rats. The changes in lipid peroxidation 
status and anti-oxidant enzymes (super-oxide dismutase, glutathione peroxidase 
and catalase) levels observed in diabetic rats, were significantly restored by 
EL and glib treatment. Decrease in Na-K+ ATPase activity was also significantly 
restored by EL. Glibenclamide was used as standard drug in present study. Conclusion: 
This study provided experimental evidence to preventive effect of EL on nerve 
function and oxidative stress in animal model of diabetic neuropathy. Hence EL 
may be tried clinically for the treatment of diabetic neuropathy since it was 
used as folk medicine in diabetic patients.