@article {10.3844/ajidsp.2008.244.256,
article_type = {journal},
title = {Passive Transfer of HIV-1 Antibodies and Drug Resistant Virus during a Health Care Worker Accident: Implications for HCW Post-Exposure Management},
author = {De Oliveira, Carlos Fernando and Diaz, Ricardo Sobhie and Harmache, Abdallah and Frenkel, Lisa M. and Gupta, Phalguni and Learn, Gerald H. and Mullins, James I. and Busch, Michael P.},
volume = {4},
number = {4},
year = {2008},
month = {Dec},
pages = {244-256},
doi = {10.3844/ajidsp.2008.244.256},
url = {https://thescipub.com/abstract/ajidsp.2008.244.256},
abstract = {Problem statement: We studied in detail a case in which a nurse caring for an HIV-infected child suffered a deep-laceration accident with contaminated blood. Approach: The patient had been treated with zidovudine (ZDV) and the nurse became infected despite prophylactic use of ZDV initiated 2 h after the accident. A reactive anti-HIV-1/2 EIA and an indeterminate western blot (gp120/160 reactivity) were obtained from the nurse on the day of the accident, suggesting preexposure infection. However, a negative western blot and positive DNA PCR were documented 10 days after the accident and seroconversion occurred an additional two weeks later. Results: Phylogenetic analyses of HIV-1 tat and C2-C4-gp120 env regions confirmed that the nurse infected by two different HIV-1 strains present in the child. Strains present in both subjects revealed multinucleoside resistant HIV-1. Dilutional serological studies using 10 HIV-infected patients’ sera demonstrated that passive seroreactivity could occur with infusion of less than 1 uL of blood when highly sensitive assays are employed. Conclusion: This is the first well-documented case of passive HIV antibody detection after a percutaneous exposure. Reactive baseline serology should not be assumed to represent prior infection nor exclude prophylaxis. Transmission of drug-resistant HIV-1 corroborates the medical history and supports use of drug history and resistance testing to guide antiretroviral prophylaxis.},
journal = {American Journal of Infectious Diseases},
publisher = {Science Publications}
}