@article {10.3844/ajessp.2013.439.445, article_type = {journal}, title = {Selenium Effect on Hyperoxia-Induced Glutathione Peroxidase Activity and Free Radicals Production in the Brain}, author = {Bin-Jaliah, Ismaeel}, volume = {9}, number = {5}, year = {2013}, month = {Dec}, pages = {439-445}, doi = {10.3844/ajessp.2013.439.445}, url = {https://thescipub.com/abstract/ajessp.2013.439.445}, abstract = {The purpose of this study was to examine the behavior of Glutathione Peroxidase (GPx) activity and Free Radicals (FR) production in the brain during graded hyperoxia exposure with and without selenium preventive intake. Forty two adult male rats were assigned to seven groups, six animals each. The first group served as control and the second, third and fourth groups were exposed to hyperoxia for 24, 48 and 72 h, respectively. The fifth, six and seventh groups were exposed to hyperoxia for 24, 48 and 72 h with selenium treatment. Following the exposure period for each group animals were sacrificed and brain tissues were homogenized for GPx and FR analysis. The results of 2-way ANOVA showed that the main effects of both selenium and hyperoxia were significant (p}, journal = {American Journal of Environmental Sciences}, publisher = {Science Publications} }