@article {10.3844/ajbbsp.2025.401.411, article_type = {journal}, title = {Optimization of α-Glucosidase Inhibitors Recovery from Rainbow Trout Hydrolysate Using GA-BP Neural Network}, author = {Chu, Yingke and Dong, Yanling and Rong, Qingfeng and Yang, Kun and Zhu, Lanlan}, volume = {21}, number = {3}, year = {2026}, month = {Jan}, pages = {401-411}, doi = {10.3844/ajbbsp.2025.401.411}, url = {https://thescipub.com/abstract/ajbbsp.2025.401.411}, abstract = {To enhance the value of by-products from rainbow trout processing, the inhibition rate of α-glucosidase (AGIR) is used as indicators. Optimization of rainbow trout hydrolysate extraction by comparing Response Surface Methodology (RSM) and BP Neural Network (BPNN) models. The RSM results: the AGIR is 55.02%. BPNN models predicted the optimal extraction conditions: 51℃ for temperature,1:2.3 for solid-liquid ratio, 4.15 h for time and 0.2334% for enzyme dosage. The reactions obtained under optimized conditions are as follows: the α-glucosidase inhibitory rate increased to 58.14%. This proves that the BPNN model can simultaneously improve the hydrolysis degree and α-glucosidase inhibition rate of the rainbow trout hydrolysate.}, journal = {American Journal of Biochemistry and Biotechnology}, publisher = {Science Publications} }