TY  - JOUR
AU  - Zou, Yanan 
AU  - Liang, Qiong 
AU  - Liu, Lu 
AU  - Li, Dingguo 
AU  - Wang, Ting 
AU  - Pan, Mingzhu 
AU  - Zong, Tongxiang 
AU  - Zhang, Yuxia 
PY  - 2025
TI  - Dose-Dependent Neurotoxic Effects of Monosodium Glutamate and its Potential Genetic Transmission in Mice
JF  - American Journal of Biochemistry and Biotechnology
VL  - 21
IS  - 3
DO  - 10.3844/ajbbsp.2025.287.296
UR  - https://thescipub.com/abstract/ajbbsp.2025.287.296
AB  - This study aimed to preliminarily investigated the neurotoxic effects of monosodium glutamate on mice and their pups, and the potential possibility of a genetic mechanism influencing the pups. In this study, mice were given different doses of Monosodium Glutamate (MSG) at doses of 2.0 or 4.0 g/kg body weight for 10 continuous days, and its impacts on both the mice and their pups were evaluated by means of appearance assessments, morphological examination and animal behavior experiments. The results showed that high doses of MSG induced clear, dose-dependent toxic symptoms in both mice and their pups. Increasing MSG dosage resulted in greater brain injury in both mice and their pups, along with more pronounced deficits in Y-maze and water maze learning and memory, heightened central nervous system excitability, the inhibition of the exploratory and curious behaviors of the pups, and the more serious the damage to the high-altitude coordinated motor performance. These findings provide a foundation for studying the dose-dependent damage to the central nervous system in mice caused by exogenous glutamate and its potential genetic effects on pups.