@article {10.3844/ajbbsp.2010.204.212,
article_type = {journal},
title = {Impact of L-Carnitine and Cinnamon on Insulin-Like Growth Factor-1 and Inducible Nitric Oxide Synthase Gene Expression in Heart and Brain of Insulin Resistant Rats},
author = {Mohamed, Mona A.},
volume = {6},
number = {3},
year = {2010},
month = {Sep},
pages = {204-212},
doi = {10.3844/ajbbsp.2010.204.212},
url = {https://thescipub.com/abstract/ajbbsp.2010.204.212},
abstract = {Problem statement: Evaluate the effects of daily administration of L-carnitine and
cinnamon extract for two weeks on the expression of Insulin-like Growth Factor-1 (IGF-1) and
inducible Nitric Oxide Synthase (iNOS) genes in cardiac and brain tissues of rats with Insulin
Resistance (IR). Approach: Rats were divided into 4 groups (8 animals each): Group (1) rats fed
control diet (60% starch) as control while groups (2, 3 and 4) fed high fructose diet (60% fructose). At
the beginning of the 3rd week of feeding, rats of group (3) were treated with L-carnitine (300 mg kg-1
body weight/day, i.p.) and animals of group (4) received a daily oral dose of cinnamon aqueous extract
(0.5 mL rat-1). The animals were maintained in their respective groups for 4 weeks. Results:
Feeding high fructose diet causes significant reduction in Insulin Receptor Substrate-1 (IRS-1)
(amounted 30.65%) and elevation in iNOS expression (reached 51%) in the cardiac tissues as
compared to control. In brain tissues, the IGF-1 mRNA was reduced in fructose loaded groups
(28.81%). Administration of either L-carnitine or cinnamon extract significantly improves the
expression of the cardiac studied genes but with no effects on the brain tissues. Conclusion: The
present study illustrated that CE was more potent than L-carnitine in improving the IR.},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}