@article {10.3844/ajbbsp.2005.37.42, article_type = {journal}, title = {Correlation between Tissue and Released VEGF Levels in Urine of Bladder Cancer Patients}, author = {Swellam, Menha and El-Aal, Abdulla A.A.}, volume = {1}, number = {1}, year = {2005}, month = {Mar}, pages = {37-42}, doi = {10.3844/ajbbsp.2005.37.42}, url = {https://thescipub.com/abstract/ajbbsp.2005.37.42}, abstract = {Purpose. Angiogenesis is a complex multistep process essential for tumor growth. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and vascular permeability-inducing agent. The aim of this study was to analyze whether tissue and urinary VEGF levels of bladder cancer patients are correlated and study their correlation with classical clinicopathological parameters and bilharizial bladder cancer patients. The study group was consisted of consecutive series of 120 bladder cancer patients. VEGF levels were measured by an enzyme immunoassay method (EIA). We evaluated EIA method for quantifying tissue and urinary VEGF levels with intra-assay CVs of 7.3-9.2% and 6.7-9.5%; and inter-assay CVs of 8.3-9.1% and 6.7-9% respectively. The recovery of tissue VEGF level was 96-99% and urinary VEGF was 97-101%. A high significant association was observed between tissue and urinary VEGF levels (p}, journal = {American Journal of Biochemistry and Biotechnology}, publisher = {Science Publications} }