TY  - JOUR
AU  - Ismaiel, Sally I. 
AU  - Farouk, Sameh M. 
AU  - El-Ramady, Raafat A. 
AU  - Khalil, Waleed F. 
PY  - 2017
TI  - Ameliorative Impacts of Tribulus terrestris Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study
JF  - American Journal of Animal and Veterinary Sciences
VL  - 12
IS  - 1
DO  - 10.3844/ajavsp.2017.8.16
UR  - https://thescipub.com/abstract/ajavsp.2017.8.16
AB  - The current work aimed to investigate the protective effects of Tribulus terrestris extracts against ivermectin-induced hepatic and renal toxicity in male rabbit. Selenium plus vitamin E was used as a comparative standard drug to evaluate the efficacy of Tribulus terrestris extract on some hematological parameters, kidney and liver enzymes as well as associated histopathological changes. This work was carried out on thirty male New Zealand rabbits for two successive months. Animals were divided into five groups of six rabbits each. The 1st group was designated as the negative control; the 2nd group was subcutaneously injected with ivermectin (IVM) (200µg/kg/month). The 3rd group was treated daily with selenium plus vitamin E (Se + vit E) after IVM injection. The 4th and 5th groups were treated with Tribulus terrestris Ethanol Extract (TTE) and Tribulus Terrestris Ethyl Acetate extract (TTEA) respectively at a dose of 5mg/kg/day after IVM injection. Hematological results showed significant (P