@article {10.3844/ajavsp.2015.112.132, article_type = {journal}, title = {Clinio-Pathological Changes in Goats Challenged with Corynebacterium Peudotuberculosis and its Exotoxin (PLD)}, author = {Mahmood, Z. K.H. and Jesse, F. F. and Saharee, A. A. and Jasni, S. and Yusoff, R. and Wahid, H.}, volume = {10}, number = {3}, year = {2015}, month = {May}, pages = {112-132}, doi = {10.3844/ajavsp.2015.112.132}, url = {https://thescipub.com/abstract/ajavsp.2015.112.132}, abstract = {Caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is a paucity of data about the C. pseudotuberculosis exotoxin, phospholipase D (PLD) response during the course of CLA. Therefore, this study was conducted to observe the clinical signs and the cellular changes after an experimental infection of the C. pseudotuberculosis and phospholipase D challenge. Twenty six crossbred Boer goats aged 12-14 months were divided into 3 groups; the first group n=6 was inoculated with 1ml sterile PBS s.c. as the control. The second group n=10 was inoculated with live C. pseudotuberculosis 1×109 cfu s.c. The third group n=10 was i.v. inoculated with PLD 1mL/20 kg, BW. Both the C. pseudotuberculosis and the PLD treated groups showed a significant increase (p}, journal = {American Journal of Animal and Veterinary Sciences}, publisher = {Science Publications} }