TY  - JOUR
AU  - Ali, Omar Suwaidan 
AU  - Adamu, Lawan 
AU  - Abdullah, Faez Firdaus Jesse 
AU  - Ilyasu, Yusuf 
AU  - Abba, Yusuf 
AU  - Hamzah, Hazilawati Binti 
AU  - Mohd-Azmi, M. L. 
AU  - Haron, Abdul Wahid B. 
AU  - Saad, Mohd Zamri B. 
PY  - 2014
TI  - Alterations in Interleukin-1β and Interleukin-6 in Mice Inoculated Through the Oral Routes Using Graded Doses of p. Multocida Type b: 2 and its Lipopolysaccharide
JF  - American Journal of Animal and Veterinary Sciences
VL  - 10
IS  - 1
DO  - 10.3844/ajavsp.2015.1.8
UR  - https://thescipub.com/abstract/ajavsp.2015.1.8
AB  - The gram-negative bacterium Pasteurella multocida serotype B: 2 is an important veterinary and opportunistic human pathogen that causes deplorable welfare problems and colossal economic production losses in bovine and other animal species throughout the world. Pasteurella multocida type B: 2 and its LPS are associated with Haemorrhagic Septicaemia (HS) in mice as animal model. Sixty healthy Balb c mice were placed in twelve plastic cages each one containing five mice. The mice were divided into three major groups (A, B and C). Group A is the control group (n = 10) and these were inoculated with 0.4 mL of PBS pH 7.4 orally. The treatment groups (B; n = 25 and C; n = 25) were inoculated with P. multocida type B: 2 and lipopolysaccharide respectively. The mice in group B and C were further divided into five subgroups. The subgroups were designated based on the graded doses as B101, B103, B105, B107 and B109 for Pasteurella multocida and C101, C103, C105, C107 and C109 for LPS respectively. The mice were observed for 120 h post-inoculation. The concentration of IL-1β was significantly higher (p