@article {10.3844/ajavsp.2010.163.167,
article_type = {journal},
title = {Immune Response and Pasteurella Resistance in Rabbits Fed Diets Containing Various Amounts of Black Cumin Seeds},
author = {El Bagir, Nabiela M. and Farah, Imtitha T.O. and Elhag, Safia M.B. and Alhaidary, Ahmed and Mohamed, Hasab E. and Beynen, Anton C.},
volume = {5},
number = {2},
year = {2010},
month = {Jun},
pages = {163-167},
doi = {10.3844/ajavsp.2010.163.167},
url = {https://thescipub.com/abstract/ajavsp.2010.163.167},
abstract = {Problem statement: The consumption of black cumin (Nigella sativa) seed has immunomodulatory and anti-bacterial activity, but in rabbits this had   not   yet been tested. Approach:  In the present studies, rabbits were fed diets without or with black cumin seed and antibody production, phagocytotic activity, hypersensitivity and resistance against Pasteurellosis were assessed. Results: Feeding black cumin seed significantly increased serum concentrations of antibodies in response to intramusculary injected serum bovine albumin. Blood derived from rabbits fed the diets containing either 15 or 20% black cumin seed significantly reduced the growth of Staphylococcus aureus on sheep-blood agar plates. Skin thickness as index of hypersensitivity towards tuberculin was significantly reduced at 48 h after intradermal injection of the agent. Ingestion of black cumin seed significantly extended survival time after intraperitoneal administration of Pasteurella multocida. Conclusion: The feeding of black cumin seed to rabbits stimulated their immune system, but did not enhance inflammation.},
journal = {American Journal of Animal and Veterinary Sciences},
publisher = {Science Publications}
}