@article {10.3844/ajassp.2010.1317.1320,
article_type = {journal},
title = {Quality evaluation of Ketoprofen Solid Dosage Forms Available in the Pharma-Market of Bangladesh},
author = {Naher, Kamrun and Murshid, Gazi Md. Monjur and Hossain, Md. Golam and Islam, Md. Amirul and Hasan, Sheik Sayeed and Uddin, Sarder Nasir},
volume = {7},
year = {2010},
month = {Oct},
pages = {1317-1320},
doi = {10.3844/ajassp.2010.1317.1320},
url = {https://thescipub.com/abstract/ajassp.2010.1317.1320},
abstract = {Problem statement: Ketoprofen, a widely used analgesic and anti-inflammatory drug, was
available in two types of solid dosage forms in the pharma-market of Bangladesh: enteric-coated tablet
and capsule of sustained-release pattern. Seven brands of ketoprofen enteric-coated tablets and four
brands of ketoprofen sustained release capsules were studied for their in-vitro release behavior as well
as potency status. Approach: The studies were carried out to compare with standard sample of
ketoprofen sustained-release pellets and that of ketoprofen powder. To determine the release pattern of
the preparations, disintegration study and dissolution tests were performed as per the method described
in standard pharmacopeial compendia (British Pharmacopoeia or BP and United State Pharmacopoeia
or USP respectively). The potency of the samples were determined by the UV spectroscopic method as
described in BP. Results: Out of seven samples of tablets, two brands (KT-03 and KT-07) were found
noncompliant in respect of disintegration test in acid stage whereas rest of the brands complied with
BP specification in buffer stage at pH 6.8. The dissolution study of ketoprofen tablets were carried out
in both acid and buffer stages and all the samples satisfied with USP specification in both stages. All of
the brands of ketoprofen capsule also complied with the USP specification. Two brands (KT-03 and
KT-07) of tablets were found non-compliant whereas rest brands of tablets and all brands of capsules
exerted compliance in respect of potency. Conclusion: This study will provide a basis for further in-vivo
bioavailability studies of these brands to draw a more conclusive remark regarding quality status
of these samples.},
journal = {American Journal of Applied Sciences},
publisher = {Science Publications}
}