Comparison of the Analgesic Efficacy of Two Medications in Patients Receiving Dental Implants a Randomized Controlled Trial

Abstract

The aim of this randomized control trial was to compare the analgesic efficacy of two commonly prescribed medications, mefenamic acid (Ponstan™ Forte) and lysine clonixinate (Dorixina®) in patients undergoing dental implant surgery. A total of 130 patients receiving dental implants were randomized into two groups: 75 treated with Mefenamic Acid (MA) and 75 with Lysine Clonixinate (LC). The primary outcome was the change in pain scores according to a Visual Analog Scale (VAS) recorded by the patients on a questionnaire over 7 days post-operatively. Secondary outcome was analgesic consumption taken as a rescue medication. 102 patients (78.5%) completed questionnaires and were available for analysis. No significant difference was found for both outcome measures during the first 4 days     post-operative. However, the mean VAS score was significantly lower in LC group at days 5, 6 and 7 compared to MA group. The results of this study suggests that there is no difference in the analgesic efficacy between MA and LC when prescribed as pain medications following dental implant surgery. The abovementioned findings will help clinicians to have a better understanding of the analgesic efficacy of two different medications in implant surgery. When anti-inflammatory drugs are contraindicated in patients undergoing implant treatment, LC can be safely prescribed with the same analgesic efficacy of an AINS.