Ribavirin Plus Therapy in Covid-19-A Single-Center Experience
- 1 Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, India
- 2 Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, India
- 3 Community and Family Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, India
- 4 Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Rishikesh, India
Abstract
COVID-19 infection has a similar clinical spectrum of disease presentation such as SARS and MERS in the past. These led to the assumption of the possibility to treat COVID-19 infection with antivirals which had been used to treat SARS and MERS. A retrospective analysis was done in symptomatic adult patients of COVID-19 infection to explore whether ribavirin antiviral combinations reduce the need for both Noninvasive and Invasive Ventilation (NIV/IV) in the treatment of COVID-19 infections. Cohort A consisted of 40 patients who received the standard therapy and Cohort B of 61 patients who received the ribavirin plus therapy (Ribavirin with Hydroxychloroquine or Lopinavir/Ritonavir). Cohort A required NIV and IV each in 12.5% of patients while Cohort B required the same in 18.03 and 16.39% of patients respectively (p = 0.456). There was a similar trend of reduction of organ dysfunctions with time in cohort A compared to B. The study concluded there was no statistically significant reduction in the need for ventilation (non-invasive/invasive) and the development of multi-organ dysfunction in COVID-19 patients treated with ribavirin plus therapy, rather clinically standard therapy was better in all aspects.
DOI: https://doi.org/10.3844/ajptsp.2023.1.7
Copyright: © 2023 Budha Oinam Singh, Gaurav Chikara, Prasan Kumar Panda, Yogesh Arvind Bahurupi, Sarama Saha and Venkatesh Srinivasa Pai. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Antivirals
- Coronavirus Disease 2019
- Hydroxychloroquine
- Lopinavir/Ritonavir
- Multi-Organ Dysfunction
- Ribavirin