Research Article Open Access

Sesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In Rat

Kaneez F. Shad1, Suhail Al-Salam2 and Alaaeldin A. Hamza2
  • 1 Karachi University, Pakistan
  • 2 UAE University UAE, United Arab Emirates

Abstract

The therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl contents and catalase activity (as markers of oxidative stress). The cardiotoxicity damage in DOX treated rats was accompanied by histo pathological changes such as necrosis and apoptosis in cardiac tissues. These biochemical and histological disturbances were effectively attenuated on pretreatment with sesame oil (5ml/kg). These data suggest that sesame oil may be a suitable cardio protector during DOX treatment.

American Journal of Pharmacology and Toxicology
Volume 2 No. 4, 2007, 159-163

DOI: https://doi.org/10.3844/ajptsp.2007.159.163

Submitted On: 27 May 2007 Published On: 31 December 2007

How to Cite: Shad, K. F., Al-Salam, S. & Hamza, A. A. (2007). Sesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In Rat . American Journal of Pharmacology and Toxicology, 2(4), 159-163. https://doi.org/10.3844/ajptsp.2007.159.163

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Keywords

  • Doxorubicin
  • Cardio toxicity
  • Oxidative stress
  • Protective effect of Sesame oil