Research Article Open Access

A Novel Glucan-Sulforaphane Combination Stimulates Immune Response to Influenza in Mouse Model

Vetvicka Vaclav1 and Vetvickova Jana1
  • 1 University of Louisville, United States

Abstract

Influenza remains a serious health problem and causes approximately 500,000 deaths world-wide. With current available treatments offering neither dependable protection nor a rapid cure, many have focused their attention to alternative treatments. The aim of this study was to evaluate the possible effect of a novel maitake glucan-sulforaphane combination on immune response against influenza challenge in mice. We evaluated the effects of a glucan-sulforaphane combination on basic immune reactions, virus titre and overall survival after influenza infection. Results: We found 2 weeks supplementation with this glucan-sulforaphane combination significantly improved immunosuppression caused by the viral infection. Based on these results, we conclude that the significant immunostimulation caused by this combination helps to overcome virus-dependent suppression of defense reactions and that addition of sulforaphane to glucan can improve already established biological effects of glucan.

American Journal of Immunology
Volume 12 No. 2, 2016, 20-28

DOI: https://doi.org/10.3844/ajisp.2016.20.28

Submitted On: 6 May 2016 Published On: 3 August 2016

How to Cite: Vaclav, V. & Jana, V. (2016). A Novel Glucan-Sulforaphane Combination Stimulates Immune Response to Influenza in Mouse Model. American Journal of Immunology, 12(2), 20-28. https://doi.org/10.3844/ajisp.2016.20.28

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Keywords

  • Glucan
  • Sulforaphane
  • Influenza
  • Immune System
  • Virus