Analysis of the Clinical Incidence and Correlation between Colorectal Cancer and Microorganisms
- 1 Pathology, Cleveland Clinic Weston, Florida, United States
Abstract
In this single institution retrospective medical record review, patients diagnosed with colorectal cancer from the years 2018-2022 were evaluated to distinguish an associative linear relationship between diagnosed colorectal cancer and a positive result for the presence of an infectious microorganism. A total of 241 patients diagnosed with colorectal cancer accompanied by a test or order placed with the purpose of ruling out or identifying a microorganism were compiled. The data were analyzed on a linear model to determine association between the two variables and to further investigate trends associated with the presence of a dominant microorganism and the characteristics of the colorectal cancer. Based on the observed clinical incidence, the greatest presence of a dominant infectious microorganism occurred in patients with left sided colon cancers. Species evaluation within this cohort found similarity to microorganisms identified as common post-treatment infectious pathogens including Escherichia coli, Enterococcus faecalis and Streptococcus species. The apparent trend of a dominant microorganism within left sided colorectal cancers suggests clinical relevance when considering further treatment and management of infections within this population.
DOI: https://doi.org/10.3844/ajidsp.2024.11.23
Copyright: © 2024 Kalia Koutouvalis and Pablo Augusto Bejarano. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Colorectal Carcinoma
- Concurrent Infection
- Colon Cancer Screening
- Infectious Microorganisms