Case Report Open Access

Portal Vein Thrombosis: A Saga of two Nebulous Etiologies

Ashwin Parchani1, Manjunath Totaganti1, Prasan Kumar Panda1 and Sunil Kumar KS2
  • 1 All India Institute of Medical Sciences (AIIMS), India
  • 2 All India Institute of Medical Sciences (AIIMS) Rishikesh, India


Portal Vein Thrombosis (PVT) is the most prevalent cause of extrahepatic portal vein obstruction. Cirrhosis, inherited procoagulant conditions (such as Factor V Leiden, Antithrombin III deficiency, etc.), myeloproliferative neoplasms, hepatocellular carcinoma and operative manipulation of the portal vein are all common causes of portal vein thrombosis. Even though a diagnosis is usually made, more than 25% of patients have no clear explanation for their PVT. The authors describe two cases of portal vein thrombosis in an atypical setting-one in a middle-aged female with type 2 diabetes mellitus with pyoperitoneum and the other is in a young male coinfected with human immunodeficiency virus and hepatitis E virus. Both cases had very different outcomes and thus emphasized the notion that PVT is a potentially fatal condition demanding a thorough diagnostic workup and evaluation.

American Journal of Infectious Diseases
Volume 18 No. 1, 2022, 21-25


Submitted On: 7 October 2021 Published On: 26 March 2022

How to Cite: Parchani, A., Totaganti, M., Panda, P. K. & KS, S. K. (2022). Portal Vein Thrombosis: A Saga of two Nebulous Etiologies. American Journal of Infectious Diseases, 18(1), 21-25.

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  • Human Immunodeficiency Virus
  • Hepatitis E
  • Peritonitis
  • Venous Thromboembolism