Research Article Open Access

Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications

Sotirios Tsiodras1 and Christos Mantzoros1
  • 1 Beth Israel Deaconess Medical Center, United States

Abstract

Leptin and adiponectin represent two newly discovered adipose tissue derived hormones with important roles in energy homeostasis and insulin resistance. Their interrelations with the manifestations of the HIV associated metabolic syndrome and specific somatomorphic changes i.e. fat redistribution is reviewed. A synopsis of published studies is presented and the potential role of leptin and adiponectin is discussed. We have described an association of the HIV metabolic syndrome with a state of reduced insulin sensitivity due to adiponectin deficiency. The metabolic syndrome is also accompanied by leptin deficiency in lipoatrophic subjects and possibly by a leptin resistance state in lipohypertrophic patients. Adiponectin and / or leptin therapy in a manner similar to other leptin deficiency states may assist in the future management of such patients.

American Journal of Infectious Diseases
Volume 2 No. 3, 2006, 141-152

DOI: https://doi.org/10.3844/ajidsp.2006.141.152

Submitted On: 13 July 2006 Published On: 30 September 2006

How to Cite: Tsiodras, S. & Mantzoros, C. (2006). Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications. American Journal of Infectious Diseases, 2(3), 141-152. https://doi.org/10.3844/ajidsp.2006.141.152

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Keywords

  • HIV
  • adipokine
  • adipocytokines
  • adiponectin
  • metabolic syndrome
  • insulin resistance