Research Article Open Access

An Unusual Association between Chromoblastomycosis and Jorge Lobo’s Disease in the Same Patient from the Amazon Region

Maurimelia M. da Costa1, Silvia H. Marques da Silva1, Hugo J. R. Almeida1, Francisco Lúzio de P. Ramos1, Maysa de Vasconcelos Brito2, Deborah Unger2, Clívia Oliveira2, Marília Brasil Xavier2, Arival Cardoso de Brito2 and Juarez Antonio Simões Quaresma2
  • 1 Evandro Chagas Institute, SVS, Ministry of Health, Ananindeua, PA, Brazil
  • 2 Tropical Medicine Unit, Federal do Para University, Belem, PA, Brazil

Abstract

A clinical case of co-infection Cladophialophora sp. and Lacazia loboi is described and in a same patient with an 18-year history of verrucous plaques and parakeloidal nodular lesions. A 50-yearold man, a laborer, living in the Anajás city, Para, Brazil (rural Amazon region), was seen at the Evandro Chagas Institute’s ambulatory. Histopathological analysis revealed intense hyperplasia and hyperkeratosis of the epidermis, sometimes showing well-circumscribed areas of an intraepidermal suppurative content intermingled with round and brownish structures. The papillary and reticular dermis was characterized by fibrosis and a granulomatous reaction consisting of lymphocytes, histiocytes and giant cells permeated by suppurative inflammatory foci and multiple round fungal structures mainly arranged amidst a neutrophilic inflammatory infiltrate. The clinical material collected from the lesion was submitted to direct mycological examination using 20% KOH solution and lactophenol cotton blue, which revealed the presence of yeast-like cells with a double membrane arranged in groups, a characteristic of Lacazia loboi, as well as sclerotic cells characteristic of chromoblastomycosis. Culture of the specimen on Mycosel agar and microculture on potato agar showed the typical morphology of Cladophialophora sp. The association of these two fungi causing lesions and inducing long-term disease may indicate a similarity in the characteristics of the habitat of these agents in the Amazon region.

American Journal of Agricultural and Biological Sciences
Volume 3 No. 3, 2008, 575-578

DOI: https://doi.org/10.3844/ajabssp.2008.575.578

Submitted On: 4 October 2007 Published On: 30 September 2008

How to Cite: da Costa, M. M., Marques da Silva, S. H., Almeida, H. J. R., P. Ramos, F. L. D., Brito, M. V., Unger, D., Oliveira, C., Xavier, M. B., de Brito, A. C. & Quaresma, J. A. S. (2008). An Unusual Association between Chromoblastomycosis and Jorge Lobo’s Disease in the Same Patient from the Amazon Region . American Journal of Agricultural and Biological Sciences, 3(3), 575-578. https://doi.org/10.3844/ajabssp.2008.575.578

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Keywords

  • Mycoses
  • fungus
  • Amazon
  • lacaziosis