Research Article Open Access

Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro

Aroonsri Priprem1, Chidchanok Khamlert1, Thaned Pongjanyakul1, Sarayut Radapong1, Theera Rittirod1 and Padungkwan Chitropas1
  • 1 Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand

Abstract

Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol-1, pKa 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, fully hydrated. A receptor solution at pH 7.4 was sampled for quantification at its λmax by UV-Visible spectrophotometry and/or HPLC. The permeability coefficients of nine compounds were correlated to the n-octanol/water partition coefficients of these compounds. The permeability coefficient of these compounds using HE and SSS was correlated. Scales of shed skin from the dorsal portions of king cobras were shown to be well correlated to the human breast epidermis in this in vitro aqueous permeation study of these compounds.

American Journal of Agricultural and Biological Sciences
Volume 3 No. 1, 2008, 444-450

DOI: https://doi.org/10.3844/ajabssp.2008.444.450

Submitted On: 12 October 2007 Published On: 31 March 2008

How to Cite: Priprem, A., Khamlert, C., Pongjanyakul, T., Radapong, S., Rittirod, T. & Chitropas, P. (2008). Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro. American Journal of Agricultural and Biological Sciences, 3(1), 444-450. https://doi.org/10.3844/ajabssp.2008.444.450

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Keywords

  • Scale region
  • shed king cobra skin
  • human skin
  • permeation
  • barrier membrane