Research Article Open Access

Intranasal Administration of Quercetin Liposome Decreases Anxiety-like Behavior and Increases Spatial Memory

Jintanaporn Wattanathorn1, Wathita Phachonpai2, Aroonsri Priprem3 and Saengrawee Suthiparinyanont4
  • 1 Department of Physiology, Faculty of Medicine, Khon Kaen University, Thailand
  • 2 Department of Physiology (Neuroscience Program) and Graduate School, Faculty of Medicine and Graduate School, Khon Kaen University, Thailand
  • 3 Department of Technology and Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
  • 4 Department of Technology and Pharmaceutical Sciences and Graduate School, Khon Kaen University, Thailand

Abstract

At present, the effects of quercetin liposome on anxiolytic activity and cognitive function are unclearly known. In this study, male Wistar rats were administered quercetin liposome via intranasal route once daily continually for 4 weeks. The anxiolytic activity and cognitive enhancing effect were determined after single administration, 1, 2, 3 and 4 weeks of treatment using elevated plus maze test and Morris water maze test respectively. The results showed that quercetin liposome significantly increased both number of opened arm entry and time spent in the opened arm. In addition, the quercetin liposome also decreased escape latency and increased retention time markedly. Therefore, our results demonstrated the anxiolytic activity and cognitive enhancing effect of quercetin liposome and suggested that it might be used as a novel therapeutic strategy for anxiety disorder and cognitive deficit condition.

American Journal of Agricultural and Biological Sciences
Volume 2 No. 1, 2007, 31-35

DOI: https://doi.org/10.3844/ajabssp.2007.31.35

Submitted On: 7 March 2007 Published On: 31 March 2007

How to Cite: Wattanathorn, J., Phachonpai, W., Priprem, A. & Suthiparinyanont, S. (2007). Intranasal Administration of Quercetin Liposome Decreases Anxiety-like Behavior and Increases Spatial Memory. American Journal of Agricultural and Biological Sciences, 2(1), 31-35. https://doi.org/10.3844/ajabssp.2007.31.35

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Keywords

  • Quercetin
  • liposome
  • anxiolytic activity
  • cognitive function
  • intranasal route
  • elevated plus maze
  • morris water maze test