Research Article Open Access

Physicochemical Characteristics and Sub Chronic Oral Toxicity of Pistacia lentiscus L. Vegetable Oil in Rabbits

Maameri Zineb1, Zouhir Djerrou2, Sofiane Habibatni1, Foulla Riachi3, Hadria Djaalab1 and Youcef Hamdi Pacha1
  • 1 University of Mentouri Constantine, Algeria
  • 2 University of August 20th 1955, Algeria
  • 3 University of Mentouri Constantine, Albania

Abstract

Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this oil were similar to those reported for similar oils [density: 0.915, refractive index: 1.46; acid value (mg KOH/g): 8.4; saponification value (mg KOH/g): 187.5]. The sub-chronic toxicity test conducted in rabbits at different doses (0.5, 1 and 2 mL kg-1) for 28 days via oral route did not result in any signs of toxicity. The biochemicals results indicate that this oil maintain rates of ALT and AST in the physiological norms. A significant decrease in blood glucose was registered, but always within the physiological standards. Other experimental studies are required to accomplish the pharmacotoxicological profile of this vegetable oil which is in spreading use.

OnLine Journal of Biological Sciences
Volume 16 No. 1, 2016, 43-48

DOI: https://doi.org/10.3844/ojbsci.2016.43.48

Submitted On: 30 December 2015 Published On: 13 January 2016

How to Cite: Zineb, M., Djerrou, Z., Habibatni, S., Riachi, F., Djaalab, H. & Pacha, Y. H. (2016). Physicochemical Characteristics and Sub Chronic Oral Toxicity of Pistacia lentiscus L. Vegetable Oil in Rabbits. OnLine Journal of Biological Sciences, 16(1), 43-48. https://doi.org/10.3844/ojbsci.2016.43.48

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Keywords

  • Pistacia lentiscus L.
  • Vegetable Oil
  • Physicochemical Characterization
  • Oral Toxicity
  • Rabbits